| CAS | 148498-78-6 |
| Sequence | H-Tyr-Ile-Gly-Ser-Arg-NH2 |
| Sequence Single | YIGSR-NH2 |
| Molecular Formula | C26H43N9O7 |
| Molecular Weight | 110590-65-3 |
| Synonyms | Laminin Penta Peptide, amide |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Cancer Research|Cell Culture|Regenerative Medicine |
| Description | YIGSR-amide also called Laminin Penta Peptide, amide, binds to the laminin receptor and inhibits experimental metastasis formation. In comparison to YIGSR, C-terminal amidation increases the activity of the peptide significantly. |
| References | 1. Receptor-mediated gene transfer to cells of hepatic origin by galactosylated albumin-polylysine complexes. J.Han et al., Biol. Pharm. Bull., 22, 836 (1999) 2. Amino acids and peptides. XIV. Laminin related peptides and their inhibitory effect on experimental metastasis formation. K.Kawasaki et al., Biochem. Biophys. Res. Commun., 174, 1159 (1991) 3. YIGSR, a synthetic laminin pentapeptide, inhibits experimental metastasis formation. Y.Iwamoto et al., Science, 238, 1132 (1987) 4. Conformational studies of antimetastatic laminin-1 derived peptides in different solvent systems, using solution NMR spectroscopy. M.Jaseja et al., J. Pept. Res., 61, 24 (2003) |