| CAS | 183598-56-3 |
| Sequence | H-Val-Pro-Ile-Gln-Lys-Val-Gln-Asp-Asp-Thr-Lys-Thr-Leu-Ile-Lys-Thr-Ile-Val-Thr-Arg-Ile-Asn-Asp-Ile-Ser-His-Thr-Gln-Ser-Val-Ser-Ser-Lys-Gln-Lys-OH |
| Sequence Single | VPIQKVQDDTKTLIKTIVTRINDISHTQSVSSKQK |
| Molecular Formula | C171H298N50O56 |
| Molecular Weight | 3950.55 |
| Synonyms | Obese Gene Peptide (22-56) (human) |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Obesity Research |
| Description | Leptin (22-56) (human) also called Obese Gene Peptide (22-56) (human), is a peptide with the seuqence of VPIQKVQDDTKTLIKTIVTRINDISHTQSVSSKQK. After central administration of this leptin (22-56) by feeding in the rat inhibition of food intake was observed. Leptin (22-56) depolarized rat hypothalamic paraventricular nucleus neurons. Leptin (22-56) was shown to enhance the proliferative activity of both the normal myometrium and myoma cells in primary culture. |
| References | 1. Potent, structurally constrained agonists and competitive antagonists of corticotropin-releasing factor. J.Gulyas et al., Proc. Natl. Acad. Sci. USA, 92, 10575 (1995) 2. A 35 amino acid fragment of leptin inhibits feeding in the rat. W.K.Samson et al., Endocrinology, 137, 5182 (1996) 3. Leptin depolarizes rat hypothalamic paraventricular nucleus neurons. J.E.Powis et al., Am. J. Physiol., 274, R1468 (1998) |