Laminin β-1 Chain (929-933) (human, mouse) Laminin Fragments Catalog

CAS	148498-78-6
Sequence	H-Tyr-Ile-Gly-Ser-Arg-OH
Sequence Single	YIGSR
Molecular Formula	C26H42N8O8
Molecular Weight	110590-64-2
Synonyms	YIGSR, Laminin Fragment (929-933)
Technology	Synthetic
Storage	-20°C, avoid light, cool and dry place
Application	Adhesion Molecules & Extracellular Matrix Proteins\|Cancer Research\|Cell Culture\|Regenerative Medicine
Description	Laminin β-1 Chain (929-933) (human, mouse) also called YIGSR, Laminin Fragment (929-933), is a pentapeptide with the sequence of YIGSR, it located within domain III of the laminin B1 chain, represents a major receptor binding site in laminin. By competing with laminin for the cell surface receptor, laminin β-1 Chain (929-933) is able to inhibit cell attachment to basement membranes, thus preventing the formation of tumor metastases. Laminin β-1 Chain (929-933) also promotes tumor cell migration and, moreover, mediates the adhesion of a variety of epithelial cells to laminin.
References	1. Stress and eating: a dual role for bombesin-like peptides. Z.Merali et al., Front. Neurosci., 7, 193 (2013) 2. Synthetic pentapeptide from the B1 chain of laminin promotes B16F10 melanoma cell migration. Y.Iwamoto et al., J. Cell. Physiol., 134, 287 (1988) 3. The role of laminin in cancer invasion and metastasis. G.Hunt, Exp. Cell Biol., 57, 165 (1989) 4. YIGSR, a synthetic laminin pentapeptide, inhibits experimental metastasis formation. Y.Iwamoto et al., Science, 238, 1132 (1987)

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