| Sequence | Ac-Arg-Arg-Trp-Pro-Arg-(S)-2-(4-pentenyl)alanine-Ile-Leu-Asp-(S)-2-(4-pentenyl)alanine-His-Val-Arg-Arg-Val-Trp-Arg-Ala-Leu-Ala-Pro-Tyr-Ile-Pro-NH2(Stapled together with a double bond between (S)-2-(4-pentenyl)alanine) |
| Sequence Single | RRWPRXILDXHVRRVWRALAPYIP(Modifications: Arg-1 = N-terminal Ac, X = (S)-2-(4-pentenyl)alanine, X-6 and X-10 stapled together with a double bond, Arg-17 = Arg-Ahx, Pro-24 = C-terminal amide) |
| Molecular Formula | C154H244N48O29 |
| Molecular Weight | 3231.89 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | β-catenin Peptides |
| Description | xStAx-VHLL is a selective peptide-based β-catenin Degrader. xStAx-VHLL comprises a β-catenin-targeted stapled peptide, xStAx, linked to a VHL-binding peptide. xStAx-VHLL reduces β-catenin levels in HEK293T cells and colorectal cancer cell lines. xStAx-VHLL selectively degrades β-catenin over other Wnt signaling pathway components. xStAx-VHLL inhibits tumor growth in APCmin/+ mice, with constitutively active Wnt signaling, and reduces survival of patient-derived colorectal cancer cell organoids. |
| References | 1. A PROTAC peptide induces durable β-catenin degradation and suppresses Wnt-dependent intestinal cancer. Liao et al (2020). Cell Discov. 6 35 PMID: 32550000 |