| CAS | 211364-78-2 |
| Sequence | H-Pro-His-Cys-Val-Pro-Arg-Asp-Leu-Ser-Trp-Leu-Asp-Leu-Glu-Ala-Asn-Met-Cys-Leu-Pro-OH |
| Sequence Single | PHCVPRDLSWLDLEANMCLP |
| Molecular Formula | C101H157N27O29S3 |
| Molecular Weight | 2309.69 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | 14.3.3 Protein Peptides |
| Description | R18 is an antagonist of 14.3.3 proteins (KD ≈80 nM). R18 competitively inhibits 14.3.3-ligand interactions without requiring phosphorylation. R18 blocks the ability of 14.3.3 to bind to target proteins such as Raf-1, Bad, ASK1 and exoenzyme S. |
| References | 1. Isolation of high-affinity peptide antagonists of 14.3.3 proteins by phage display. Wang et al (1999). Biochemistry 38 12499 PMID: 10493820 2. 14.3.3 proteins mediate an essential anti-apoptotic signal. Masters and Fu (2001). J.Biol.Chem. 276 45193 PMID: 11577088 |