| Sequence | H-Pro-Lys-Lys-Lys-Arg-Lys-Val-PEG2-homoArg-homoArg-Trp-Pro-homoArg-(S)-2-(4-pentenyl)alanine-Ile-Leu-Asp-(S)-2-(4-pentenyl)alanine-His-Val-homoArg-homoArg-Val-Trp-homoArg-NH2(Stapled together with a double bond between (S)-2-(4-pentenyl)alanine) |
| Sequence Single | PKKKRKVRRWPRXILDXHVRRVWR-NH2(Modifications: Val-7 = Val-PEG2, Arg-8 = Arg-9 = Arg-12 = Arg-20 = Arg-21 = homo-Arg, X = (S)-2-(4-pentenyl)alanine, X-13 and X-17 stapled together with a double bond, Arg-24 = homo-Arg & C-terminal amide) |
| Molecular Formula | C161H275N55O29 |
| Molecular Weight | 3445.26 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | β-catenin Peptides |
| Description | NLS-StAx-h is a Wnt inhibitor (IC50 = 1.4 μM). NLS-StAx-h is a stapled peptide inhibitor of oncogenic Wnt signaling. NLS-StAx-h inhibits β-catenin-transcription factor interactions. NLS-StAx-h inhibits proliferation and migration of colorectal cancer cells. NLS-StAx-h is cell permeable. |
| References | 1. Cell permeable stapled peptide inhibitor of Wnt signaling that targets beta -catenin protein-protein Interactions. Dietrich et al (2017). Cell Chem.Biol. 24 958 PMID: 28757184 |