Uroguanylin Topoisomer A (human) Guanylin and Uroguanylin Catalog

CAS	154525-25-4
Sequence	H-Asn-Asp-Asp-Cys-Glu-Leu-Cys-Val-Asn-Val-Ala-Cys-Thr-Gly-Cys-Leu-OH (Disulfide bonds between Cys4 and Cys12/Cys7 and Cys15)
Sequence Single	NDDCELCVNVACTGCL
Molecular Formula	C64H102N18O26S4
Molecular Weight	1667.88
Synonyms	UGN (human), UGN Topoisomer A (human)
Technology	Synthetic
Storage	-20°C, avoid light, cool and dry place
Application	Gastrointestinal Research\|Obesity Research
Description	Uroguanylin belongs to the guanylin family of cyclic guanosine monophosphate (cGMP) regulating peptides. This family of peptides shows homology to the heat stable enterotoxins produced by strains of Escherichia coli and other enteric bacteria that cause a secretory form of diarrhea. Along with the isolation of uroguanylin from urine and the subsequent demonstration of its natriuretic activity by direct effects on the kidney, uroguanylin has been suggested to play a role in the physiological maintenance of sodium balance in vivo. Uroguanylin activation of the guanylate cyclase-C/cyclic guanosine monophosphate pathway elicited analgesic effects in animal models of colonic hypersensitivity, unraveling a novel pathway to treat abdominal pain (Silos-Santiago et al. (2013)).
References	1. Novel peptide inhibitors of angiotensin-converting enzyme 2. L.Huang et al., J. Biol. Chem., 278, 15532 (2003) 2. Uroguanylin: how the gut got another satiety hormone. R.J.Seeley and M.H.Tschöp, J. Clin. Invest., 121, 3384 (2011) 3. Gastrointestinal pain: unraveling a novel endogenous pathway through uroguanylin/guanylate cyclase-C/cGMP activation. I.Silos-Santiago et al., Pain, 154, 1820 (2013) 4. Characterization of human uroguanylin: a member of the guanylin peptide family. T.Kita et al., Am. J. Physiol., 266, F342 (1994) 5. A novel role for uroguanylin in the regulation of sodium balance. L.R.Forte, J. Clin. Invest., 112, 1138 (2003)

PeptideDB

Uroguanylin Topoisomer A (human)

CAS No.: 154525-25-4