| Sequence | H-Asn-Asp-Asp-Cys-Glu-Leu-Cys-Val-Asn-Val-Ala-Cys-Thr-Gly-Cys-Leu-OH (Disulfide bonds between Cys4 and Cys12/Cys7 and Cys15) |
| Sequence Single | NDDCELCVNVACTGCL |
| Molecular Formula | C64H102N18O26S4 |
| Molecular Weight | 1667.88 |
| Synonyms | UGN Topoisomer B (human) |
| Application | Gastrointestinal Research|Obesity Research |
| Description | Uroguanylin Topoisomer B (human) is a short peptides containing two disulfide bridges which can form interconvertible topoisomers with the same disulfide connectivity. In case of uroguanylin (UGN), both are relatively stable and can be separated, and interconversion is slow. The topoisomers differ in biological activity: The UGN A topomer potently activates the guanylate cyclase C receptor found primarily in the intestine. The B topomer is a very weak agonist of this receptor. Moss et al. could show that UGN B has potent natriuretic activity in the kidney. |
| References | 1. Synthesis and characterization of human alpha-defensins 4-6. Z.Wu et al., J. Pept. Res., 64, 118 (2004) 2. One peptide, two topologies: structure and interconversion dynamics of human uroguanylin isomers. U.C.Marx et al., J. Pept. Res., 52, 229 (1998) 3. The natriuretic peptide uroguanylin elicits physiologic actions through 2 distinct topoisomers. N.G.Moss et al., Hypertension, 53, 867 (2009) |