| CAS | 176591-49-4 |
| Sequence | H-Asp-Asn-Pro-Ser-Leu-Ser-Ile-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Thr-Leu-Leu-Glu-Leu-Ala-Arg-Thr-Gln-Ser-Gln-Arg-Glu-Arg-Ala-Glu-Gln-Asn-Arg-Ile-Ile-Phe-Asp-Ser-Val-NH2 |
| Sequence Single | DNPSLSIDLTFHLLRTLLELARTQSQRERAEQNRIIFDSV-NH2 |
| Molecular Formula | C204H337N63O64 |
| Molecular Weight | 4696.31 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Description | Urocortin (human), a 40-aa neuropeptide, acts as a selective agonist of endogenous CRF2 receptor, with Kis of 0.4, 0.3, and 0.5 nM for hCRF1, rCRF2α and mCRF2β, respectively. |
| References | 1. Solid-phase synthesis of the cyclic lipononadepsipeptide [N-Mst(Ser1), d-Ser4, L-Thr6, L-Asp8, L-Thr9]syringotoxin. N.Bayo et al., Chem. Eur. J., 9, 1096 (2003) 2. Corticotropin-releasing factor receptors 1 and 2 in anxiety and depression. Reul JM, et al. Curr Opin Pharmacol. 2002 Feb;2(1):23-33. 3. The neurobiology of urocortin. Skelton KH, et al. Regul Pept. 2000 Sep 25;93(1-3):85-92. |