| CAS | 171543-83-2 |
| Sequence | H-Asp-Asp-Pro-Pro-Leu-Ser-Ile-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Thr-Leu-Leu-Glu-Leu-Ala-Arg-Thr-Gln-Ser-Gln-Arg-Glu-Arg-Ala-Glu-Gln-Asn-Arg-Ile-Ile-Phe-Asp-Ser-Val-NH2 |
| Sequence Single | DDPPLSIDLTFHLLRTLLELARTQSQRERAEQNRIIFDSV-NH2 |
| Molecular Formula | C206H338N62O64 |
| Molecular Weight | 4707.33 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Description | Urocortin (rat) is a neuropeptide and a potent endogenous CRFR agonist with Kis of 13 nM, 1.5 nM, and 0.97 nM for human CRF1, rat CRF2α and mouse CRF2β, respectively. |
| References | 1. A 21-mer synthetic peptide of toxic shock syndrome toxin 1, TSST-1[58-78], activates T cells by binding to MHC class II and by an MHC unrestricted xenostimulatory pathway. A.Haregewoin et al., Immunol. Invest., 23, 413 (1994) 2. Corticotropin-releasing factor receptors 1 and 2 in anxiety and depression. Reul JM, et al. Curr Opin Pharmacol. 2002 Feb;2(1):23-33. 3. The neurobiology of urocortin. Skelton KH, et al. Regul Pept. 2000 Sep 25;93(1-3):85-92. 4. Corticotropin releasing factor receptors and their ligand family. Perrin MH, et al. Ann N Y Acad Sci. 1999 Oct 20;885:312-28. |