| CAS | 77591-33-4 |
| Sequence | Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser-OH |
| Sequence Single | Ac-SDKPDMAEIEKFDKSKLKKTETQEKNPLPSKETIEQEKQAGES |
| Molecular Formula | C212H350N56O78S |
| Molecular Weight | 4963.49 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Description | Thymosin β4 is a naturally occuring, potent regulator of actin polymerization present in human platelets at a concentration of 200 - 500 μM. Thymosin β4 can sequesters G-actin monomers in a 1:1 ratio (Kd = 0.7 - 1.0 μM) and allow rapid filament polymerization in the presence of profilin. Thymosin β4 implicated in wound healing, induction of MMPs, chemotaxis, angiogenesis, inflammatory processes and tumor progression. |
| References | 1. Thymosin β10 and thymosin β4 are both actin monomer sequestering proteins. Yu et al (1993). J.Biol.Chem. 268 502 PMID: 8416954 2. β-thymosins, small acidic peptides with multiple functions. Huff et al (2001). Int.J.Biochem.Cell Biol. 33 205 PMID: 11311852 3. Thymosin β4 and angiogenesis: modes of action and therapeutic potential. Smart et al (2007). Angiogenesis 10 229 PMID: 17632766 |