| Sequence | H-Ala-Leu-Cys-Asn-Cys-Asn-Arg-Ile-Ile-Ile-Pro-Leu-Gln-Cys-Trp-Lys-Lys-Cys-Gly-Lys-Lys-NH2 (Disulfide bridge between 3 - 14, 5 - 18) |
| Sequence Single | ALCNCNRIIIPLQCWKKCGKK-NH2 (Disulfide bridge between 3 - 14, 5 - 18) |
| Molecular Formula | C106H179N33O24S4 |
| Molecular Weight | 2428.03 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Description | Tertiapin LQ is a blocker of Kir1.1 channels; displays >250-fold selectivity for Kir1.1 (Kd values are 1.1, 274 and 361 nM for Kir1.1, Kir3.1/3.2 and Kir3.1/3.4 respectively). Tertiapin LQ is a derivative of tertiapin-Q. |
| References | 1. Engineered specific and high-affinity inhibitor for a subtype of inward-rectifier K+ channels. Ramu et al (2008). Proc.Natl.Acad.Sci.USA 105 10774 PMID: 18669667 |