| CAS | 53749-60-3 |
| Sequence | H-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 |
| Sequence Single | PQQFFGLM-NH2 |
| Molecular Formula | C46H67N11O10S |
| Molecular Weight | 966.17 |
| Synonyms | Octa-Substance P |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Description | Substance P (4-11) also called Octa-Substance P, is a C-terminus fragment of Substance P, it seems to be more active than the natural peptide in various pharmacological tests in vitro and in vivo. Substance P (4-11) was shown to be an agonist of the NK1 receptor, IC50 = 15 nM. |
| References | 1. Specific stimulation of human T lymphocytes by substance P. D G Payan, et al. J Immunol. 1983 Oct;131(4):1613-5. 2. Substance P induces ion secretion in mouse small intestine through effects on enteric nerves and mast cells. L Wang, et al. Am J Physiol. 1995 Jul;269(1 Pt 1):G85-92. 3. Sensory neuropeptides (substance P) and 4-11 SP enhance human neutrophils chemiluminescence; the role of L-arginine. P Cornaglia-Ferraris, et al. Int J Immunopharmacol. 1986;8(4):463-8. |