| CAS | 188425-80-1 |
| Sequence | Stearyl-Asp-Leu-Ile-Glu-Glu-Ala-Ala-Ser-Arg-Ile-Val-Asp-Ala-Val-Ile-Glu-Gln-Val-Lys-Ala-Ala-Gly-Ala-Tyr-OH |
| Sequence Single | Ste-DLIEEAASRIVDAVIEQVKAAGAY |
| Molecular Formula | C129H217N29O39 |
| Molecular Weight | 2798.27 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | A-Kinase-Anchoring Proteins Peptides Inhibitors |
| Description | st-Ht31 is a stearated form of the peptide Ht-31. st-Ht31 inhibits the interaction between the RII subunits of cAMP-dependent PKA and A-kinase anchoring protein (AKAP) in cell extracts. st-Ht31 is cell permeable. |
| References | 1. AKAP-mediated feedback control of cAMP gradients in developing hippocampal neurons. Gorshkov et al (2017). Nat.Chem.Biol. 13 425 PMID: 28192412 2. Protein kinase A-anchoring inhibitor peptides arrest mammalian sperm motility. Vijayaraghavan et al (1997). J.Biol.Chem. 272 4747 PMID: 9030527 3. Association of the type II cAMP-dependent protein kinase with a human thyroid RII-anchoring protein. Cloning and characterization of the RII-binding domain. Carr et al (1992). J.Biol.Chem. 267 13376 PMID: 1618839 4. Disruption of protein kinase A localization induces acrosomal exocytosis in capacitated mouse sperm. Stival et al (2018). J.Biol.Chem. 293 9435 PMID: 29700114 |