| Sequence | NH2-PEG3-CH2-Leu-(S)-2-(4-pentenyl)alanine-Gln-Tyr-Ala-(S)-2-(4-pentenyl)alanine-Gln-Leu-Ala-Asp-Gln-Ile-Ile-Lys-Glu-Ala-Thr-Glu-Lys-OH((S)-2-(4-pentenyl)alanine stapled together with a double bond) |
| Sequence Single | NH2-PEG3-CH2-LXQYAXQLADQIIKEATEK(Modifications: Leu-1 = NH2-PEG3-CH2-CO-Leu, X = (S)-2-(4-pentenyl)alanine, X-2 and X-6 stapled together with a double bond) |
| Molecular Formula | C109H181N25O35 |
| Molecular Weight | 2401.75 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | A-Kinase-Anchoring Proteins Peptides Inhibitors |
| Description | RI-STAD 2 is an AKAP disruptor. RI-STAD 2 selectively binds PKA-RI with high affinity (KD values are 6.2 and 12.1 nM for the RIα and β subunits, respectively) and blocks its interaction with AKAP. RI-STAD 2 inhibits type I PKA-mediated phosphorylation in live cells. RI-STAD 2 is cell permeable. |
| References | 1. PKA-type I selective constrained peptide disruptors of AKAP complexes. Wang et al (2015). ACS Chem.Biol. 10 1502 PMID: 25765284 |