| CAS | 1542100-77-5 |
| Sequence | NH2-PEG3-CH2-Lys-Lys-Leu-Ala-Lys-Phe-Leu-Val-Ser-(S)-2-(4-pentenyl)alanine-Ala-Leu-Lys-(S)-2-(4-pentenyl)alanine-Ala-Leu-Lys-OH((S)-2-(4-pentenyl)alanine stapled together with a double bond) |
| Sequence Single | NH2-PEG3-CH2-KKLAKFLVSXALKXALK(Modifications: X = (S)-2-(4-pentenyl)alanine, X-10 and X-14 stapled together with a double bond) |
| Molecular Formula | C102H182N24O22 |
| Molecular Weight | 2096.68 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | A-Kinase-Anchoring Proteins Peptides Inhibitors |
| Description | STAD 2 is an AKAP disruptor. STAD 2 selectively binds PKA-RII subunit with high affinity (Kd = 6.2 nM) and blocks its interaction with AKAP. STAD 2 is cell permeable. STAD 2 is selectively permeable to malaria-infected red blood cells and displays antimalarial activity through a PKA-independent mechanism. |
| References | 1. Investigating PKA-RII specificity using analogs of the PKA:AKAP peptide inhibitor STAD-2. Bendzunas et al (2018). Bioorg.Med.Chem. 26 1174 PMID: 29449124 2. The stapled AKAP disruptor peptide STAD-2 displays antimalarial activity through a PKA-independent mechanism. Flaherty et al (2015). PLoS One 10 e0129239 PMID: 26010880 3. Isoform-selective disruption of AKAP-localized PKA using hydrocarbon stapled peptides. Wang et al (2014). ACS Chem.Biol. 9 635 PMID: 24422448 |