| CAS | 121695-87-2 |
| Sequence | H-Cys-Thr-Cys-Asn-Asp-Met-Thr-Asp-Glu-Glu-Cys-Leu-Asn-Phe-Cys-His-Gln-Asp-Val-Ile-Trp-OH (Disulfide bonds between Cys1 and Cys15/Cys3 and Cys11) |
| Sequence Single | CTCNDMTDEECLNFCHQDVIW |
| Molecular Formula | C103H147N27O37S5 |
| Molecular Weight | 2515.79 |
| Synonyms | SRTX-C, S6C, Sarafotoxin S6c |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Cardiovascular System & Diseases |
| Description | Sarafotoxin C also called SRTX-C, S6C, Sarafotoxin S6c, is a potent endothelin-B receptor agonist. Sarafotoxin C can cause vasoconstriction in both endothelium-intact and endothelium-denuded vessels. |
| References | 1. Effects of sarafotoxin S6c on antidiuresis and NE overflow induced by stimulation of renal nerves in anesthetized dogs. Matsuo et al (1997). J.Pharmacol.Exp.Ther. 280 905 PMID: 9023305 2. Distinct endothelin-B receptors mediate the effects of sarafotoxin S6c and IRL 1620 in the ileum. Miasiro et al (1998). J.Cardiovasc.Pharmacol. 31 S175 PMID: 9595431 3. Sarafotoxin S6c: an agonist which distinguishes between endothelin receptor subtypes. Williams et al (1991). Biochem.Biophys.Res.Commun. 175 556 PMID: 1850245 4. Characterization of cloned human endothelin receptors. Williams et al (1993). Life Sci. 53 407 PMID: 8336519 5. Effects of pulmonary hypertension on vasoconstrictor responses to endothelin-1 and sarafotoxin S6C and on inherent tone in rat pulmonary arteries. MacLean MR, et al. J Cardiovasc Pharmacol. 1995 Nov;26(5):822-30. |