| CAS | 876310-60-0 |
| Sequence | 1-Adamantanecarbonyl-Arg-Phe-NH2 |
| Sequence Single | 1-Adamantanecarbonyl-RF-NH2 |
| Molecular Formula | C26H38N6O3 |
| Molecular Weight | 482.63 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Cardiovascular System & Diseases|Opioid Research |
| Description | RF9 is a potent and selective Neuropeptide FF receptor antagonist, with Ki values of 58 and 75 nM for hNPFF1R and hNPFF2R, respectively. RF9 (1-Adamantanecarbonyl-Arg-Phe-NH2) blocked the delayed and long-lasting paradoxical opioid-induced hyperalgesia and prevented the development of associated tolerance. RF9 could also efficiently block the increase in blood pressure and heart rate evoked by NPFF. |
| References | 1. Chymase-dependent generation of angiotensin II from angiotensin-(1-12) in human atrial tissue. S.Ahmad et al., PLoS One, 6, e28501 (2011) 2. Characterization of the potent gonadotropin-releasing activity of RF9, a selective antagonist of RF-amide-related peptides and neuropeptide FF receptors: physiological and pharmacological implications. R.Pineda et al., Endocrinology, 151, 1902 (2010) 3. RF9 powerfully stimulates gonadotrophin secretion in the ewe: evidence for a seasonal threshold of sensitivity. A.Caraty et al., J. Neuroendocrinol., 24, 725 (2012) 4. RF9, a potent and selective neuropeptide FF receptor antagonist, prevents opioid-induced tolerance associated with hyperalgesia. F.Simonin et al., Proc. Natl. Acad. Sci. USA, 103, 466 (2006) |