| CAS | 99489-94-8 |
| Sequence | (Pyr-Leu-Tyr-Ser-Ala-Leu-Ala-Asn-Lys-Cys-Cys-His-Val-Gly-Cys-Thr-Lys-Arg-Ser-Leu-Ala-Arg-Phe-Cys-OH)A(H-Asp-Ser-Trp-Met-Glu-Glu-Val-Ile-Lys-Leu-Cys-Gly-Arg-Glu-Leu-Val-Arg-Ala-Gln-Ile-Ala-Ile-Cys-Gly-Met-Ser-Thr-Trp-Ser-OH)B (Disulfide bonds between Cys10A and Cys15A/Cys11A and Cys11B/Cys24A and Cys23B) |
| Sequence Single | (Pyr-LYSALANKCCHVGCTKRSLARFC)A(DSWMEEVIKLCGRELVRAQIAICGMSTWS)B(Disulfide bonds between Cys10A and Cys15A/Cys11A and Cys11B/Cys24A and Cys23B) |
| Molecular Formula | C256H408N74O74S8 |
| Molecular Weight | 5963.04 |
| Synonyms | Serelaxin |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Cardiovascular System & Diseases|Reproductive Medicine |
| Description | Relaxin H2 (human) also called Serelaxin, is the major stored and circulating isoform of the peptide hormone relaxin in humans. Relaxin H2 has also shown cardioprotective activity. The observed long-term effects of relaxin H2 on connective tissues may be due to alterations in the turnover of collagen and proteoglycans. |
| References | 1. Adipokinetic hormone-induced lipolysis in the fat body of an insect, Manduca sexta: synthesis of sn-1,2-diacylglycerols. E.L.Arrese and M.A.Wells, J. Lipid Res., 38, 68 (1997) 2. Relaxin in cardiovascular and renal disease. C.S.Samuel and T.D.Hewitson, Kidney Int., 69, 1498 (2006) 3. A novel, adenylate cyclase, signaling mechanism of relaxin H2 action. A.Shpakov et al., Ann. N. Y. Acad. Sci., 1041, 305 (2005) 4. An autocrine/paracrine role of human decidual relaxin. I. Interstitial collagenase (matrix metalloproteinase-1) and tissue plasminogen activator. X.Qin et al., Biol. Reprod., 56, 800 (1997) 5. Relaxin binding in the rat heart atrium. P.L.Osheroff et al., Proc. Natl. Acad. Sci. USA, 89, 2384 (1992) 6. Relaxin antagonizes hypertrophy and apoptosis in neonatal rat cardiomyocytes. X.-l.Moore et al., Endocrinology, 148, 1582 (2007) 7. Does the relaxin, estrogen and matrix metalloproteinase axis contribute to degradation of TMJ fibrocartilage? S.Kapila, J. Musculoskelet. Neuronal Interact., 3, 401 (2003) |