| CAS | 1158181-62-4 |
| Sequence | (H-Asp-Val-Leu-Ala-Gly-Leu-Ser-Ser-Ser-Cys-Cys-Lys-Trp-Gly-Cys-Ser-Lys-Ser-Glu-Ile-Ser-Ser-Leu-Cys-OH)A(H-Arg-Ala-Ala-Pro-Tyr-Gly-Val-Arg-Leu-Cys-Gly-Arg-Glu-Phe-Ile-Arg-Ala-Val-Ile-Phe-Thr-Cys-Gly-Gly-Ser-Arg-Trp-OH)B (Disulfide bonds between Cys10A and Cys15A/Cys11A and Cys10B/Cys24A and Cys22B) |
| Sequence Single | DVLAGLSSSCCKWGCSKSEISSLC)A(RAAPYGCRLCGREFIRAVIFTCGGSRW)B(Disulfide bonds between Cys10A and Cys15A/Cys11A and Cys10B/Cys24A and Cys22B) |
| Molecular Formula | C237H374N70O69S6 |
| Molecular Weight | 5500.4 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Adhesion Molecules & Extracellular Matrix Proteins |
| Description | Relaxin H3 (human) is a specific ligand for the leucine-rich repeat-containing G protein-coupled receptor LGR7. Hossain et al. demonstrated that relaxin H3 exerts antifibrotic actions via the relaxin receptor RXFP1 and may enhance the collagen-inhibitory effects of relaxin H2. |
| References | 1. Synthesis of Enantiomerically Pure Unsaturated .alpha.-Amino Acids Using Serine-Derived Zinc/Copper Reagents. M.J.Dunn et al., J. Org. Chem., 60, 2210 (1995) 2. Responses of GPCR135 to human gene 3 (H3) relaxin in CHO-K1 cells determined by microphysiometry. E.T.van der Westhuizen et al., Ann. N. Y. Acad. Sci., 1041, 332 (2005) 3. H2 relaxin is a biased ligand relative to H3 relaxin at the relaxin family peptide receptor 3 (RXFP3). E.T.van der Westhuizen et al., Mol. Pharmacol., 77, 759 (2010) 4. Human relaxin gene 3 (H3) and the equivalent mouse relaxin (M3) gene. Novel members of the relaxin peptide family. R.A.Bathgate et al., J. Biol. Chem., 277, 1148 (2002) 5. H3 relaxin is a specific ligand for LGR7 and activates the receptor by interacting with both the ectodomain and the exoloop 2. S.Sudo et al., J. Biol. Chem., 278, 7855 (2003) |