| CAS | 229030-05-1 |
| Sequence | Ac-Lys-Arg-Pro-Pro-Gly-(αMe)Phe-Ser-DβNal-Ile-OH |
| Sequence Single | Ac-KRPPG-(αMe)Phe-S-DβNal-I |
| Molecular Formula | C58H83N13O12 |
| Molecular Weight | 1154.37 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Description | R 892 is a potent and selective bradykinin B1 receptor antagonist (ID50 values are 2.8 and > 600 nM at B1 and B2 receptors respectively). R 892 exhibits no intrinsic agonist activity and is resistant to aminopeptidase and kininase II (ACE) cleavage. R 892 displays hypertensive activity in vivo. |
| References | 1. Structure-activity studies of B1 receptor related peptide. Gobeil et al (1996). Hypertension 28 833 PMID: 8901831 2. Mechanisms mediating the vasoactive effects of the B1 receptors of bradykinin. Duka et al (2003). Hypertension 42 1021 PMID: 14557281 |