| CAS | 185052-09-9 |
| Sequence | Ac-Lys-Arg-Pro-Pro-Gly-Phe-Ser-D-βNal-Ile-OH |
| Sequence Single | Ac-KRPPGFS-DβNal-I |
| Molecular Formula | C57H81N13O12 |
| Molecular Weight | 1140.35 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Description | R 715 is a potent and selective bradykinin B1 receptor antagonist (pA2 = 8.49). R 715 displays no activity at B2 receptors. R 715 reduces mechanical hypernociception in a mouse model of neuropathic pain. R 715 is metabolically stable. |
| References | 1. Structure-activity studies of B1 receptor-related peptides. Gobeil et al (1996). Hypertension. 28 833 PMID: 8901831 2. Neuropathic pain-like behavior after brachial plexus avulsion in mice: the relevance of kinin B1 and B2 receptors. Quintao et al (2008). J.Neurosci. 28 2856 PMID: 18337416 3. Retinal plasma extravasation in streptozotocin-diabetic rats mediated by kinin B1 and B2 receptors. Abdouh et al (2008). Br.J.Pharmacol. 154 136 PMID: 18311190 |