| CAS | 130308-48-4 |
| Sequence | H-D-Arg-Arg-Pro-Hyp-Gly-Thi-Ser-D-Tic-Oic-Arg-OH |
| Sequence Single | D-Arg-RP-Hyp-G-Thi-S-D-Tic-Oic-R |
| Molecular Formula | C59H89N19O13S |
| Molecular Weight | 1304.52 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Description | HOE 140 is a potent and selective bradykinin B2 receptor antagonist (pA2 = 9.04). HOE 140 also inhibits aminopeptidase N (Ki = 9.1 μM). |
| References | 1. Hoe 140 a new potent and long acting bradykinin-antagonist: in vitro studies. Hock et al (1991). Br.J.Pharmacol. 102 769 PMID: 1364851 2. Agonistic and antagonistic properties of the bradykinin B2 receptor antagonist, Hoe 140, in isolated blood vessels from different species. Feletou et al (1994). Br.J.Pharmacol. 112 683 PMID: 8075888 3. The bradykinin B2 receptor antagonist icatibant (Hoe 140) blocks aminopeptidase N at micromolar concentrations: off-target alterations of signaling mediated by the bradykinin B1 and angiotensin receptors. Bawolak et al (2006). Eur.J.Pharmacol. 551 108 PMID: 17026984 |