| CAS | 126088-82-2 |
| Sequence | Boc-Gln-D-Trp(Formyl)-Phe-Obzl |
| Sequence Single | Boc-Q-D-Trp(Formyl)-Phe-Obzl |
| Molecular Formula | C38H43N5O8 |
| Molecular Weight | 697.78 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Description | QWF is a tripeptide substance P (SP) antagonist (IC50 = 90 μM). QWF also inhibits binding of SP to Mas-related GPCR (MRGPR) X2. QWF inhibits SP-induced IgE-independent degranulation of mast cells in vitro. QWF inhibits compound 48/80-induced MRGPRX2 activation and scratching in mice in vivo. |
| References | 1. Studies on neurokinin antagonists. 1. The design of novel tripeptides possessing the glutaminyl-D-tryptophylphenylalanine sequence as substance P antagonists. Hagiwara et al (1992). J.Med.Chem. 35 2015 PMID: 1375965 2. Dual action of neurokinin-1 antagonists on Mas-related GPCRs. Azimi et al (2016). JCI Insight. 1 e89362 PMID: 27734033 |