| CAS | 196305-05-2 |
| Sequence | H-Phe-Arg-Lys-Lys-Trp-Asn-Lys-Trp-Ala-Leu-Ser-Arg-NH2 |
| Sequence Single | FRKKWNKWALSR-NH2 |
| Molecular Formula | C77H119N25O14 |
| Molecular Weight | 1618.95 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Description | PAMP-12 (human, porcine) is a potent endogenous peptide agonist of Mas related GPR X2 (MRGPRX2, EC50 = 57.2 nM). PAMP-12 (human, porcine) corresponds to amino acids 9 to 20 of proadrenomedullin. |
| References | 1. Identification of MrgX2 as a human G-protein-coupled receptor for proadrenomedullin N-terminal peptides. Kamohara et al (2005). Biochem.Biophys.Res.Commun. 330 1146 PMID: 15823563 2. In silico design of novel probes for the atypical opioid receptor MRGPRX2. Lansu et al (2017). Nat.Chem.Biol. 13 529 PMID: 28288109 3. Purification and Characterization of PAMP-12 (PAMP[9-20]) in Porcine Adrenal Medulla as a Major Endogenous Biologically Active Peptide. K Kuwasako, et al. FEBS Lett. 1997 Sep 1;414(1):105-10. |