(Pyr6,Pro9)-Substance P (6-11) Substance P, Fragments, Analogs, and Antagonists Catalog

CAS	79775-19-2
Sequence	Pyr-Phe-Phe-Pro-Leu-Met-NH2
Sequence Single	pEFFPLM-NH2
Molecular Formula	C39H53N7O7S
Molecular Weight	763.96
Synonyms	Septide, [Glp6, Pro9] Substance P (6-11)
Technology	Synthetic
Storage	-20°C, avoid light, cool and dry place
Description	(Pyr6,Pro9)-Substance P (6-11) also called Septide, [Glp6, Pro9] Substance P (6-11), is a selective agonist for the substance P P-receptor subtype. (Pyr6,Pro9)-Substance P (6-11) is a selective agonist for the tachykinin NK-1 receptor with a Kd value of 0.55 nM.
References	1. Septide: an agonist for the NK1 receptor acting at a site distinct from substance P. H.P.Hartung et al., Agents Actions, 15, 14 (1984) 2. [pGlu6,Pro9]SP6-11, a selective agonist for the substance P P-receptor subtype. L.Pradier et al., Mol. Pharmacol., 45, 287 (1994) 3. Characterization of central and peripheral effects of septide with the use of five tachykinin NK1 receptor antagonists in the rat. R.Laufer et al., J. Med. Chem., 29, 1284 (1986) 4. Septide and neurokinin A are high-affinity ligands on the NK-1 receptor: evidence from homologous versus heterologous binding analysis. Hastrup H, Schwartz TW. FEBS Lett. 1996 Dec 16;399(3):264-6.

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