| CAS | 115150-59-9 |
| Sequence | H-Arg-D-Trp-N-Me-Phe-D-Trp-Leu-Met-NH2 |
| Sequence Single | Rw-N-Me-FwLM-NH2 |
| Molecular Formula | C49H66N12O6S |
| Molecular Weight | 951.21 |
| Synonyms | Antagonist G |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Cancer Research |
| Description | Substance P (6-11), also called antagonist G, is a broad-spectrum neuropeptide growth factor antagonist that inhibits the growth of small cell lung cancer (SCLC) cells. Substance P (6-11) is a potent vasopressin antagonist. Substance P (6-11) is also a weak antagonist of GRP and Bradykinin. Substance P (6-11) induces AP-1 transcription and sensitizes cells to chemotherapy. |
| References | 1. A neuropeptide antagonist that inhibits the growth of small cell lung cancer in vitro. P J Woll, et al. Cancer Res. 1990 Jul 1;50(13):3968-73. 2. [Arg6, D-Trp7,9, NmePhe8]-substance P (6–11) (antagonist G) inducesP-1 transcription and sensitizes cells to chemotherapy. A C MacKinnon, et al. Br J Cancer. 2000 Oct; 83(7): 941–948. |
(Arg6,D-Trp7.9,N-Me-Phe8)-Substance P (6-11)
CAS No.: 115150-59-9
Substance P (6-11), also called antagonist G, is a broad-spectrum neuropeptide growth factor antagonist that inhibits th
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