| CAS | 106128-89-6 |
| Sequence | Suc-Asp-Phe-N-Me-Phe-Gly-Leu-Met-NH2 |
| Sequence Single | Suc-DFFGLM-NH2 |
| Molecular Formula | C40H55N7O11S |
| Molecular Weight | 841.98 |
| Synonyms | Senktide |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Description | Succinyl-(Asp6,N-Me-Phe8)-Substance P (6-11) also called Senktide, is a specific agonist for the substance P N-receptor in guinea pig ileum. Succinyl-(Asp6,N-Me-Phe8)-Substance P (6-11) is a tachykinin NK3 receptor agonist. |
| References | 1. Topical effects of N-acetyl-L-hydroxyproline on ceramide synthesis and alleviation of pruritus E. Hashizume et al., Clin. Cosmet. Investig. Dermatol., 6, 43 (2013) 2. Highly selective agonists for substance P receptor subtypes. U.Wormser et al., EMBO J., 5, 2805 (1986) 3. Characterization of a neurokinin B receptor site in rat brain using a highly selective radioligand. R.Laufer et al., J. Biol. Chem., 261, 10257 (1986) 4. The tachykinin NK3 receptor agonist senktide induces locomotor activity in male Mongolian gerbils. Nordquist RE, et al. Eur J Pharmacol. 2008 Dec 14;600(1-3):87-92. 5. Keegan KD, et al. The selective NK3 receptor agonist senktide excites a subpopulation of dopamine-sensitiveneurones in the rat substantia nigra pars compacta in vitro. Br J Pharmacol. 1992 Jan;105(1):3-5. |
Succinyl-(Asp6,N-Me-Phe8)-Substance P (6-11)
CAS No.: 106128-89-6
Succinyl-(Asp6,N-Me-Phe8)-Substance P (6-11) also called Senktide, is a specific agonist for the substance P N-receptor
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