| CAS | 245329-02-6 |
| Sequence | H-Phe-Ser-Leu-Leu-Arg-Tyr-NH2 |
| Sequence Single | FSLLRY-NH2 |
| Molecular Formula | C39H60N10O8 |
| Molecular Weight | 796.97 |
| Synonyms | FSLLRYamide, (Phe1,Ser2,Tyr6)-Proteinase Activated Receptor 1 (1-6) amide (human), (Phe1,Ser2,Tyr6)-Thrombin Receptor (1-6) amide (human), (Phe1,Ser2,Tyr6)-Coagulation Factor II Receptor (1-6) amide (mouse) |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Cardiovascular System & Diseases|Hematology |
| Description | (Phe1,Ser2,Tyr6)-PAR-1 (1-6) amide (human) also called FSLLRYamide, (Phe1,Ser2,Tyr6)-Proteinase Activated Receptor 1 (1-6) amide (human), (Phe1,Ser2,Tyr6)-Thrombin Receptor (1-6) amide (human), (Phe1,Ser2,Tyr6)-Coagulation Factor II Receptor (1-6) amide (mouse), is a PAR-2 antagonist. (Phe1,Ser2,Tyr6)-PAR-1 (1-6) amide (human) inhibited activation of PAR-2 by trypsin in PAR-2 receptor expressing KNRK cells. Half-maximal inhibition of calcium signaling was observed at about 50 µM. In contrast, the activation of PAR-2 by SLIGRL-amide (PAR-2 (1-6) amide (mouse, rat) was not inhibited by (Phe1,Ser2,Tyr6)-PAR-1 (1-6) amide (human). |
| References | 1. Identification of peptides for immunotherapy of cancer. It is worth the effort. M.P.Velders et al., Crit. Rev. Immunol., 18, 7 (1998) 2. The membrane-anchored serine protease, TMPRSS2, activates PAR-2 in prostate cancer cells. S.Wilson et al., Biochem. J., 388, 967 (2005) 3. FSLLRY-NH2 Improves Neurological Outcome After Cardiac Arrest in Rats. Umut Ocak, et al. Turk Neurosurg. 2020;30(2):244-251. |
(Phe1,Ser2,Tyr6)-PAR-1 (1-6) amide (human)
CAS No.: 245329-02-6
(Phe1,Ser2,Tyr6)-PAR-1 (1-6) amide (human) also called FSLLRYamide, (Phe1,Ser2,Tyr6)-Proteinase Activated Receptor 1 (1-
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