| CAS | 197794-83-5 |
| Sequence | H-Thr-Phe-Leu-Leu-Arg-NH2 |
| Sequence Single | TFLLR-NH2 |
| Molecular Formula | C31H53N9O6 |
| Molecular Weight | 647.82 |
| Synonyms | TFLLRamide, (Thr1)-TRAP-5 amide, TFLLR-NH2 Protease-Activated Receptor 1 (PAR1) Agonist |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Cardiovascular System & Diseases|Hematology |
| Description | (Thr1)-PAR-1 (1-5) amide (human) also called TFLLRamide, (Thr1)-TRAP-5 amide, TFLLR-NH2 Protease-Activated Receptor 1 (PAR1) Agonist, is a selective PAR1 agonist with an EC50 of 1.9 μM. |
| References | 1. Identification and characterization of a novel sucrose-non-fermenting protein kinase/AMP-activated protein kinase-related protein kinase, SNARK. D.L.Lefebvre et al., Biochem. J., 355, 297 (2001) 2. Agonists of proteinase-activated receptor 1 induce plasma extravasation by a neurogenic mechanism. de Garavilla L, et al. Br J Pharmacol. 2001 Aug;133(7):975-87. 3. Characterization of the protease-activated receptor-1-mediated contraction and relaxation in the rat duodenal smooth muscle. Kawabata A, et al. 4. Activation of platelet protease-activated receptor-1 induces epithelial-mesenchymal transition and chemotaxis of colon cancer cell line SW620. Jia Y, et al. Oncol Rep. 2015 Jun;33(6):2681-8. |
(Thr1)-PAR-1 (1-5) amide (human)
CAS No.: 197794-83-5
(Thr1)-PAR-1 (1-5) amide (human) also called TFLLRamide, (Thr1)-TRAP-5 amide, TFLLR-NH2 Protease-Activated Receptor 1 (P
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