| CAS | 17466-45-4 |
| Sequence | Cyclo(-Ala-D-Thr-Cys-cis-Hyp-Ala-Trp-(4R)-4,5-dihydroxy-Leu) (Sulfide bond between Cys and indol-2-yl) |
| Sequence Single | Cyclo(-AtC-cis-Hyp-AW-(4R)-4,5-dihydroxy-L)(Sulfide bond between Cys and indol-2-yl) |
| Molecular Formula | C35H48N8O11S |
| Molecular Weight | 788.87 |
| Synonyms | Bicyclic(Ala-DThr-Cys-cis-4-hydroxy-Pro-Ala-2-mercapto-Trp-4,5-dihydroxy-Leu)(S-3→6), NSC 523214, 鬼笔环肽 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Description | Phalloidin also alled Bicyclic(Ala-DThr-Cys-cis-4-hydroxy-Pro-Ala-2-mercapto-Trp-4,5-dihydroxy-Leu)(S-3→6), NSC 523214, is a mushroom-derived toxin which can be used to label F-actin of the cytoskeleton with fluorochrome (λex=495 nm, λem=520 nm). |
| References | 1. Primary structural determinants essential for potent inhibition of cAMP-dependent protein kinase by inhibitory peptides corresponding to the active portion of the heat-stable inhibitor protein. D.B.Glass et al., J. Biol. Chem., 264, 8802 (1989) 2. Ribosomal biosynthesis of the cyclic peptide toxins of Amanita mushrooms. J.D.Walton et al., Biopolymers, 94, 659 (2010) 3. The toxic peptides from Amanita mushrooms. T.Wieland, Int. J. Pept. Protein Res., 22, 257 (1983) 4. Visualising the actin cytoskeleton. J.Small et al., Microsc. Res. Tech., 47, 3 (1999) 5. Labeling cytoskeletal F-actin with rhodamine phalloidin or fluorescein phalloidin for imaging. Chazotte B. Cold Spring Harb Protoc. 2010 May;2010(5):pdb.prot4947. |