Mast Cell Degranulating (MCD) Peptide Toxins Catalog

CAS	32908-73-9
Sequence	H-Ile-Lys-Cys-Asn-Cys-Lys-Arg-His-Val-Ile-Lys-Pro-His-Ile-Cys-Arg-Lys-Ile-Cys-Gly-Lys-Asn-NH2 (Disulfide bonds between Cys3 and Cys15/Cys5 and Cys19)
Sequence Single	IKCNCKRHVIKPHICRKICGKN-NH2
Molecular Formula	C110H192N40O24S4
Molecular Weight	2587.25
Synonyms	Peptide 401
Technology	Synthetic
Storage	-20°C, avoid light, cool and dry place
Application	Inflammation Research
Description	Mast Cell Degranulating (MCD) Peptide also called Peptide 401, is a highly basic peptide presented in small amounts in the venom of the European honeybee, Apis mellifera. At low doses, it causes mast cell degranulation and subsequent histamine release. At higher doses, it produces an anti-inflammatory effect, which may be beneficial in rheumatic and allergic diseases.
References	1. Antiproliferative effects of the GnRH antagonist cetrorelix and of GnRH-II on human endometrial and ovarian cancer cells are not mediated through the GnRH type I receptor. C.Gründker et al., Eur. J. Endocrinol., 151, 141 (2004) 2. Charybdotoxin, dendrotoxin and mast cell degranulating peptide block the voltage-activated K+ current of fibroblast cells stably transfected with NGK1 (Kv1.2) K+ channel complementary DNA. T.R.Werkman et al., Neuroscience, 50, 935 (1992) 3. Solid phase synthesis and biological activity of mast cell degranulating (MCD) peptide: a component of bee venom. A.Buku et al., Int. J. Pept. Protein Res., 33, 86 (1989) 4. Anti-inflammatory property of 401 (MCD-peptide), a peptide from the venom of the bee Apis mellifera (L.). Hanson JM, et al. Br J Pharmacol. 1974 Mar;50(3):383-92. 5. Anti-inflammatory activity of bee venom peptide 401 (mast cell degranulating peptide) andcompound 48/80 results from mast cell degranulation in vivo. Banks BE, et al. Br J Pharmacol. 1990 Feb;99(2):350-4.

PeptideDB

Mast Cell Degranulating (MCD) Peptide

CAS No.: 32908-73-9