| CAS | 190383-13-2 |
| Sequence | H-Ser-Leu-Ile-Gly-Lys-Val-NH2 |
| Sequence Single | SLIGKV-NH2 |
| Molecular Formula | C28H54N8O7 |
| Molecular Weight | 614.79 |
| Synonyms | SLIGKVamide, Proteinase Activated Receptor 2 (1-6) amide (human), Thrombin Receptor-Like 1 (1-6) amide (human), Coagulation Factor II Receptor-Like 1 (1-6) amide (human) |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Hematology |
| Description | PAR-2 (1-6) amide (human) also called SLIGKVamide, Proteinase Activated Receptor 2 (1-6) amide (human), Thrombin Receptor-Like 1 (1-6) amide (human), Coagulation Factor II Receptor-Like 1 (1-6) amide (human), is a highly potent protease-activated receptor-2 (PAR2) activating peptide. It corresponds to the tethered ligand sequence of human PAR-2 (protease activated receptor 2), can be used to investigate receptor functions. |
| References | 1. AMEBA: An acid sensitive aldehyde resin for solid phase synthesis. A.M.Fivush and T.M.Willson, Tetrahedron Lett., 38, 7151 (1997) 2. A polymorphic protease-activated receptor 2 (PAR2) displaying reduced sensitivity to trypsin and differential responses to PAR agonists. S.J.Compton et al., J. Biol. Chem., 275, 39207 (2000) 3. Binding of a highly potent protease-activated receptor-2 (PAR2) activating peptide, [3H]2-furoyl-LIGRL-NH2, to human PAR2. Kanke T, et al. Br J Pharmacol. 2005 May;145(2):255-63. 4. Protease-activated receptor 2 signalling promotes dendritic cell antigen transport and T-cellactivation in vivo. Ramelli G, et al. Immunology. 2010 Jan;129(1):20-7. |