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Palmitoyl-Cys((RS)-2,3-di(palmitoyloxy)-propyl)-Ser-Lys-Lys-Lys-Lys-OH

CAS No.: 112208-00-1

Palmitoyl-Cys((RS)-2,3-di(palmitoyloxy)-propyl)-Ser-Lys-Lys-Lys-Lys-OH also called Pam3Cys-Ser-Lys-Lys-Lys-Lys-OH, Pam3C
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CAS 112208-00-1
Sequence Palmitoyl-Cys((RS)-2,3-di(palmitoyloxy)-propyl)-Ser-Lys-Lys-Lys-Lys-OH
Sequence Single Pam3-CSKKKK
Molecular Formula C81H156N10O13S
Molecular Weight 1510.26
Synonyms Pam3Cys-Ser-Lys-Lys-Lys-Lys-OH, Pam3CSK4
Technology Synthetic
Storage -20°C, avoid light, cool and dry place
Application Immunomodulating Agents|Veterinary Medicine
Description Palmitoyl-Cys((RS)-2,3-di(palmitoyloxy)-propyl)-Ser-Lys-Lys-Lys-Lys-OH also called Pam3Cys-Ser-Lys-Lys-Lys-Lys-OH, Pam3CSK4, is a non-toxic lipopeptide, it is a highly effective adjuvant for parenteral, oral and nasal immunizations. It readily dissolves in aqueous solvents and might also be applicable for DNA immunizations.
References 1.  Proteinase-activated receptor-2-activating peptides induce leukocyte rolling, adhesion, and extravasation in vivo. N.Vergnolle, J. Immunol., 163, 5064 (1999) 2.  Synthesis of novel immunologically active tripalmitoyl-S-glycerylcysteinyl lipopeptides as useful intermediates for immunogen preparations. J.Metzger et al., Int. J. Pept. Protein Res., 37, 46 (1991)