Platelet Factor 4 (58-70) (human) Immunomodulating Peptides Catalog

CAS	82989-21-7
Sequence	H-Pro-Leu-Tyr-Lys-Lys-Ile-Ile-Lys-Lys-Leu-Leu-Glu-Ser-OH
Sequence Single	PLYKKIIKKLLES
Molecular Formula	C76H133N17O18
Molecular Weight	1573.01
Synonyms	PF4 (58-70) (human)
Technology	Synthetic
Storage	-20°C, avoid light, cool and dry place
Application	Antimicrobial & Antiviral Peptides\|Immunomodulating Agents
Description	Platelet Factor 4 (58-70) (human) also called PF4 (58-70) (human), is a peptide based on the amino acid sequence corresponding to residues 58-70 of platelet factor-4 (PF-4), it contains the major heparin-binding domain, which is not sufficient for full antiangiogenic activity. Like the intact platelet factor, it is able to alleviate immunosuppression in mice. It is also fully active as an inhibitor of angiogenesis in the chicken chorioallantoic membrane. The angiostatic activity is obviously associated with the C-terminal, heparin-binding region of PF4. The helical tridecapeptide shows antimicrobial activity.
References	1. Inhibition of in vitro angiogenesis by platelet factor-4-derived peptides and mechanism of action. Jouan V, et al. Blood. 1999 Aug 1;94(3):984-93.

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