| CAS | 136461-80-8 |
| Sequence | H-Tyr-Leu-Tyr-Gln-Trp-Leu-Gly-Ala-Pro-Val-Pro-Tyr-Pro-Asp-Pro-Leu-Gla-Pro-Arg-Arg-Gla-Val-Cys-Gla-Leu-Asn-Pro-Asp-Cys-Asp-Glu-Leu-Ala-Asp-His-Ile-Gly-Phe-Gln-Glu-Ala-Tyr-Arg-Arg-Phe-Tyr-Gly-Pro-Val-OH (Disulfide bond) |
| Sequence Single | YLYQWLGAPVPYPDPL-Gla-PRR-Gla-VC-Gla-LNPDCDELADHIGFQEAYRRFYGPV(Disulfide bond) |
| Molecular Formula | C269H381N67O82S2 |
| Molecular Weight | 5929.52 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Diabetes|Obesity Research|Osteoporosis Research |
| Description | Osteocalcin (1-49) (human) is a vitamin K-dependent bone specific protein. Osteocalcin (1-49) (human) is chemotactic for several of the cell types frequently found at bone remodeling surfaces. |
| References | 1. Cloning and characterization of cDNA encoding a precursor for human adrenomedullin. K.Kitamura et al., Biochem. Biophys. Res. Commun., 194, 720 (1993) 2. Bone mineral density and bone turnover in patients with knee osteoarthritis compared with generalized osteoarthritis. K.Naitou et al., Calcif. Tissue Int., 66, 325 (2000) 3. Solid-phase synthesis of human osteocalcin by using a gamma-carboxyglutamic acid derivative. T.Kurihara et al., Int. J. Pept. Protein Res., 43, 367 (1994) 4. Production of monoclonal and polyclonal antibodies against human osteocalcin sequences and development of a two-site ELISA for intact human osteocalcin. Kuronen I, et al. J Immunol Methods. 1993 Aug 9;163(2):233-40. 5. Chemotactic activity of the gamma-carboxyglutamic acid containing protein in bone. Mundy GR, et al. Calcif Tissue Int. 1983;35(2):164-8. 6. Immunoradiometric assay for intact human osteocalcin(1-49) without cross-reactivity to breakdown products. Colford JW, et al. Clin Chem. 1999 Apr;45(4):526-31. |