| CAS | 205640-91-1 |
| Sequence | H-Arg-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Ser-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2 |
| Sequence Single | RSGPPGLQGRLQRLLQASGNHAAGILTM-NH2 |
| Molecular Formula | C123H212N44O35S |
| Molecular Weight | 2899.38 |
| Synonyms | Hypocretin-2 (human) |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Obesity Research |
| Description | Orexin B (human) also called Hypocretin-2 (human). Like orexin A, orexin B (OXB) is a hypothalamic neuropeptide regulating the feeding behavior. Central administration of OXB to rats stimulated food consumption in a similar manner to orexin A, but the effect did not last as long as that of orexin A. The affinity of orexin B for the OX1 receptor is significantly lower (IC50 = 240 nM) than that of orexin A. Binding affinities for the OX2 receptor are similar for orexin A and B (IC50 = 38 nM and 36 nM, respectively, for displacement of radiolabeled orexin A bound to the receptor). |
| References | 1. Orexins and appetite: the big picture of energy homeostasis gets a little bigger. M.W.Schwartz, Nat. Med., 4, 385 (1998) 2. Evidence that NPY Y1 receptors are involved in stimulation of feeding by orexins (hypocretins) in sated rats. M.R.Jain et al., Regul. Pept., 87, 19 (2000) 3. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. T.Sakurai et al., Cell, 92, 573 (1998) |