| CAS | 343268-91-7 |
| Sequence | H-Tyr-Glu-Leu-Leu-His-Gly-Ala-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Leu-NH2 |
| Sequence Single | YELLHGAGNHAAGILTL-NH2 |
| Molecular Formula | C79H125N23O22 |
| Molecular Weight | 1749 |
| Synonyms | Hypocretin-1 (17-33) |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Obesity Research |
| Description | Orexin A (17-33) also called Hypocretin-1 (17-33), acts as selective orexin-1 receptor (OX1) antagonist, it shows a ~23-fold selectivity for the OX1 (EC50=8.29 nM) over OX2 (187 nM). Truncation studies have led to OXA (17-33) as the shortest active peptide known to date with a 23-fold selectivity for OX1 over OX2. The native orexins A and B do not show distinct receptor selectivity. Both orexin receptors are involved in energy homeostasis and the sleep/wake cycle, hence selective as well as dual antagonists are required for research. |
| References | 1. Truncated Orexin Peptides: Structure-Activity Relationship Studies. C.F.Gotfredsen et al., Diabetes, 63, 2486 (2014) |