| CAS | 147794-23-8 |
| Sequence | H-Cys-Lys-Gly-Lys-Gly-Ala-Pro-Cys-Arg-Lys-Thr-Met-Tyr-Asp-Cys-Cys-Ser-Gly-Ser-Cys-Gly-Arg-Arg-Gly-Lys-Cys-NH2 (Disulfide bonds between Cys1 and Cys16/Cys8 and Cys20/Cys15 and Cys26) |
| Sequence Single | CKGKGAPCRKTMYDCCSGSCGRRGKC-NH2 |
| Molecular Formula | C106H178N40O32S7 |
| Molecular Weight | 2749.29 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Ion Channel Modulating Agents |
| Description | Like ω-conotoxin GVIA, ω-Conotoxin MVIIC inhibits presynaptic Ca2+ channels. However, ω-conotoxin MVIIC clearly inhibits additional Ca2+ channel subtypes in the mammalian central nervous system. Thus, it should become a standard pharmacological reagent for investigating synaptic transmission in the mammalian nervous system. |
| References | 1. Inactivation of chymotrypsin and human skin chymase: kinetics of time-dependent inhibition in the presence of substrate. L.A.Johnson et al., Biochim. Biophys. Acta, 953, 269 (1988) 2. Effects of diverse omega-conopeptides on the in vivo release of glutamic and gamma-aminobutyric acids. R.Newcomb and A.Palma, Brain Res., 638, 95 (1994) 3. A new Conus peptide ligand for mammalian presynaptic Ca2+ channels. D.R.Hillyard et al., Neuron, 9, 69 (1992) |