| CAS | 74504-53-3 |
| Sequence | Pyr-Pro-Arg-Arg-Lys-Leu-Cys-Ile-Leu-His-Arg-Asn-Pro-Gly-Arg-Cys-Tyr-Asp-Lys-Ile-Pro-Ala-Phe-Tyr-Tyr-Asn-Gln-Lys-Lys-Lys-Gln-Cys-Glu-Arg-Phe-Asp-Trp-Ser-Gly-Cys-Gly-Gly-Asn-Ser-Asn-Arg-Phe-Lys-Thr-Ile-Glu-Glu-Cys-Arg-Arg-Thr-Cys-Ile-Gly-OH (Disulfide bonds between Cys7 and Cys57/Cys16 and Cys40/Cys32 and Cys53) |
| Sequence Single | pEPRRKLCILHRNPGRCYDKIPAFYYNQKKKQCERFDWSGCGGNSNRFKTIEECRRTCIG |
| Molecular Formula | C305H472N98O84S6 |
| Molecular Weight | 7048.11 |
| Synonyms | α-DTX |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Ion Channel Modulating Agents |
| Description | α-Dendrotoxin also called α-DTX, is a peptide from the venom of the Eastern green mamba, Dendroaspis angusticeps, it selectively blocks voltage-gated inactivating K+ channels in synaptosomes. |
| References | 1. Difluoromethylornithine is effective as both a preventive and therapeutic agent against the development of UV carcinogenesis in SKH hairless mice. S.M.Fischer et al., Carcinogenesis, 22, 83 (2001) 2. Toxins in the characterization of potassium channels. N.A.Castle et al., Trends Neurosci., 12, 59 (1989) 3. Tityustoxin K alpha blocks voltage-gated noninactivating K+ channels and unblocks inactivating K+ channels blocked by alpha-dendrotoxin in synaptosomes. R.S.Rogowski et al., Proc. Natl. Acad. Sci. USA, 91, 1475 (1994) 4. Four polypeptide components of green mamba venom selectively block certain potassium channels in rat brain synaptosomes. M.E.Byrnes et al., Protein Pept. Lett., 1, 239 (1995) 5. Dendrotoxins: snake toxins that block potassium channels and facilitate neurotransmitter release. C.G.Benishin et al., Mol. Pharmacol., 34, 152 (1988) 6. Toxins in the characterization of potassium channels. A.L.Harvey and A.J.Anderson, Pharmac. Ther., 31, 33 (1985) |