| CAS | 107452-89-1 |
| Sequence | H-Cys-Lys-Gly-Lys-Gly-Ala-Lys-Cys-Ser-Arg-Leu-Met-Tyr-Asp-Cys-Cys-Thr-Gly-Ser-Cys-Arg-Ser-Gly-Lys-Cys-NH2 (Disulfide bonds between Cys1 and Cys16/Cys8 and Cys20/Cys15 and Cys25) |
| Sequence Single | CKGKGAKCSRLMYDCCTGSCRSGKC-NH2 |
| Molecular Formula | C102H172N36O32S7 |
| Molecular Weight | 2639.17 |
| Synonyms | Ziconotide, SNX-111 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Ion Channel Modulating Agents |
| Description | ω-Conotoxin MVIIA also called Ziconotide, SNX-111, originally isolated from the venom of the fish-hunting cone snail Conus magus, is a blocker of voltage-sensitive Ca2+ channels in neurons. The peptide has been used to identify different Ca2+ channel subtypes in amphibian brain. |
| References | 1. An efficient conversion of the carboxylic group of N-Fmoc alpha-amino acids/peptide acids into N-formamides employing isocyanates as key intermediates. N.S.Sudarshan et al., J. Org. Chem., 72, 9804 (2007) 2. Neuronal calcium channel antagonists. Discrimination between calcium channel subtypes using omega-conotoxin from Conus magus venom. B.M.Olivera et al., Biochemistry, 26, 2086 (1987) 3. Different omega-conotoxins mark the development of Swiss Webster mouse cortex suggesting N-type voltage sensitive calcium channel subtypes. J.R.Abbott and M.J.Litzinger, Int. J. Devl Neurosci., 12, 43 (1994) 4. Effects of diverse omega-conopeptides on the in vivo release of glutamic and gamma-aminobutyric acids. R.Newcomb and A.Palma, Brain Res., 638, 95 (1994) 5. Ziconotide: a review of its pharmacology and use in the treatment of pain. Joseph G McGivern, et al. Neuropsychiatr Dis Treat. 2007 Feb;3(1):69-85. 6. Beneficial Effects of the Calcium Channel Blocker CTK 01512-2 in a Mouse Model of Multiple Sclerosis. Rodrigo B M Silva, et al. Mol Neurobiol. 2018 Dec;55(12):9307-9327. |