CAS | 152246-40-7 |
Sequence | Myristoyl-Arg-Lys-Arg-Thr-Leu-Arg-Arg-Leu-OH |
Sequence Single | Myr-RKRTLRRL |
Molecular Formula | C60H117N21O11 |
Molecular Weight | 1308.72 |
Synonyms | N-m-RKRTLRRL |
Technology | Synthetic |
Storage | -20°C, avoid light, cool and dry place |
Description | Myristoyl-Arg-Lys-Arg-Thr-Leu-Arg-Arg-Leu-OH also called N-m-RKRTLRRL, is a N-Myristylated peptide. N-Myristylation provided the octapeptide with an inhibitory activity against protein kinase C (PKC)-catalyzed Ca2+ and phosphatidylserine-dependent histone phosphorylation (IC50 = 5 µM). It has been shown that Myr-RKRTLRRL is the first synthetic PKC inhibitor with demonstrated pharmacological activity in intact cells. |