Myristoyl-Lys-Arg-Thr-Leu-Arg-OH

CAS No.: 125678-68-4

Myristoyl-Lys-Arg-Thr-Leu-Arg-OH also called N-m-KRTLR, is a myristylated pentapeptide. It is an effective inhibitor of

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CAS	125678-68-4
Sequence	Myristoyl-Lys-Arg-Thr-Leu-Arg-OH
Sequence Single	Myr-KRTLR
Molecular Formula	C42H82N12O8
Molecular Weight	883.19
Synonyms	N-m-KRTLR
Technology	Synthetic
Storage	-20°C, avoid light, cool and dry place
Description	Myristoyl-Lys-Arg-Thr-Leu-Arg-OH also called N-m-KRTLR, is a myristylated pentapeptide. It is an effective inhibitor of the protein kinase C (PKC)-catalyzed histone phosphorylation (inhibitory constant, IC50 = 75 µM). It competes with the phosphoacceptor substrate of PKC and interacts with the phospholipid cofactor of the enzyme. Myristoyl-Lys-Arg-Thr-Leu-Arg-OH inhibits IL-2 receptor induction and IL-2 production in the human leukemic cell line Jurkat.
References	1. Inhibition of IL-2 receptor induction and IL-2 production in the human leukemic cell line Jurkat by a novel peptide inhibitor of protein kinase C. Ioannides CG, et, al. Cell Immunol. 1990 Nov;131(1):242-52.

Myristoyl-Arg-Lys-Arg-Thr-Leu-Arg-Arg-Leu-OH

Myristoyl-Phe-Ala-Arg-Lys-Gly-Ala-Leu-Arg-Gln-OH