Myelin Oligodendrocyte Glycoprotein (35-55) (mouse, rat) Myelin Protein Fragments Catalog

CAS	149635-73-4
Sequence	H-Met-Glu-Val-Gly-Trp-Tyr-Arg-Ser-Pro-Phe-Ser-Arg-Val-Val-His-Leu-Tyr-Arg-Asn-Gly-Lys-OH
Sequence Single	MEVGWYRSPFSRVVHLYRNGK
Molecular Formula	C118H177N35O29S
Molecular Weight	2581.99
Synonyms	MOG (35-55) (rat, mouse)
Technology	Synthetic
Storage	-20°C, avoid light, cool and dry place
Application	Immunomodulating Agents\|Multiple Sclerosis
Description	Myelin Oligodendrocyte Glycoprotein (35-55) (mouse, rat) also called MOG (35-55) (rat, mouse), is highly encephalitogenic and can induce strong T and B cell responses. A single injection of this peptide produces a relapsing-remitting neurologic disease with extensive plaque-like demyelination. Because of the clinical, histopathologic, and immunologic similarities with multiple sclerosis (MS), this MOG-induced demyelinating encephalomyelitis may serve as a model for investigating MS.
References	1. Comparison of detergents for extraction and ion-exchange high-performance liquid chromatography of Sendai virus membrane proteins. G.W.Welling et al., J. Chromatogr., 599, 157 (1992) 2. TNF is a potent anti-inflammatory cytokine in autoimmune-mediated demyelination. J.Liu et al., Nat. Med., 4, 78 (1998)

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