Myelin Basic Protein (87-99) (human, bovine, rat) Myelin Protein Fragments Catalog

CAS	118506-26-6
Sequence	H-Val-His-Phe-Phe-Lys-Asn-Ile-Val-Thr-Pro-Arg-Thr-Pro-OH
Sequence Single	VHFFKNIVTPRTP
Molecular Formula	C74H114N20O17
Molecular Weight	1555.84
Technology	Synthetic
Storage	-20°C, avoid light, cool and dry place
Application	Immunomodulating Agents\|Multiple Sclerosis
Description	Myelin Basic Protein (87-99) (human, bovine, rat) has been shown to induce the proliferation of an encephalitogenic, myelin basic protein-specific T cell line. Active immunization of rats with this peptide induced acute experimental autoimmune encephalomyelitis. This protein region is highly conserved among mammalian species. Myelin Basic Protein(87-99) causes a Th1 polarization in peripheral blood mononuclear cells with is implicated of multiple sclerosis (MS).
References	1. Human fibrinogen: anticipating a 3-dimensional structure. R.F.Doolittle et al., FASEB J., 10, 1464 (1996) 2. The synthetic 87-99 peptide of myelin basic protein is encephalitogenic in Buffalo rats. R E Jones, et al. J Neuroimmunol. 1992 Apr;37(3):203-12. 3. Citrullination of linear and cyclic altered peptide ligands from myelin basic protein (MBP(87-99)) epitope elicits a Th1 polarized response by T cells isolated from multiple sclerosis patients: implications in triggering disease. George Deraos, et al. J M

PeptideDB