Myelin Basic Protein (85-99) Peptide Antagonist Myelin Protein Fragments Catalog

CAS	444305-16-2
Sequence	H-Glu-Lys-Pro-Lys-Val-Glu-Ala-Tyr-Lys-Ala-Ala-Ala-Ala-Pro-Ala-OH
Sequence Single	EKPKVEAYKAAAAPA
Molecular Formula	C70H114N18O21
Molecular Weight	1543.78
Synonyms	MBP (85-99) Peptide Antagonist
Technology	Synthetic
Storage	-20°C, avoid light, cool and dry place
Application	Antigen-presenting Cells\|Multiple Sclerosis
Description	Myelin Basic Protein (85-99) Peptide Antagonist also called MBP (85-99) Peptide Antagonist, is the immunodominant epitope of myelin basic protein (MBP), it is a major candidate autoantigen in multiple sclerosis (MS), for binding to human leukocyte antigen (HLA)-DR2. Myelin Basic Protein (85-99) Peptide Antagonist also inhibits IL-2 secretion by MBP (85-99) specific T-cell clones and induces the production of Th2 cytokines by splenocytes. Furthermore, it could be shown that Myelin Basic Protein (85-99) Peptide Antagonist is able to suppress experimental autoimmune encephalomyelitis (EAE) in several models in a manner that is equipotent to random amino acid copolymers, such as Copaxone [poly (Y,E,A,K)n]. Therefore, this synthetic peptide might be suitable in the studying of MS.

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