| CAS | 244082-19-7 |
| Sequence | H-Cys-Thr-Thr-His-Trp-Gly-Phe-Thr-Leu-Cys-OH (Disulfide bond) |
| Sequence Single | CTTHWGFTLC |
| Molecular Formula | C52H71N13O14S2 |
| Molecular Weight | 1166.35 |
| Synonyms | CTT |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Angiogenesis|Cancer Research|Inflammation Research |
| Description | MMP-2/MMP-9 Inhibitor III also called CTT, inhibited only gelatinases and had minimal or no effect on other MMP family members. Furthermore, the combination of tumor targeting, antiangiogenic, and anti-invasive properties of this peptide render CTT a potential lead compound for the development of peptido-mimetic anticancer agents. MMP-2/MMP-9 Inhibitor III is a cyclic peptide inhibitor for matrix metalloproteinases MMP-2 and MMP-9. The IC50 value for MMP-9 is ~8 μM. |
| References | 1. Binding of novel peptide inhibitors of type IV collagenases to phospholipid membranes and use in liposome targeting to tumor cells in vitro. Medina OP, et al. Cancer Res. 2001 May 15;61(10):3978-85. |