| CAS | 224579-74-2 |
| Sequence | H-Arg-Lys-Lys-Tyr-Lys-Tyr-Arg-Arg-Lys-NH2 |
| Sequence Single | RKKYKYRRK-NH2 |
| Molecular Formula | C60H105N23O11 |
| Molecular Weight | 1324.64 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Description | MLCK inhibitor peptide 18 is a selective competitive inhibitor of myosin light chain kinase (IC50 = 50 nM). MLCK inhibitor peptide 18 displays 4000-fold selectivity over CaM kinase II and does not inhibit PKA. MLCK inhibitor peptide 18 is cell permeable. |
| References | 1. Identification of novel classes of protein kinase inhibitors using combinatorial peptide chemistry based on functional genomics knowledge. Lukas et al (1999). J.Med.Chem. 42 910 PMID: 10072688 2. A membrane-permeant peptide that inhibits MLC kinase restores barrier function in in vitro models of intestinal disease. Zolotarevsky et al (2002). Gastroenterology 123 163 PMID: 12105845 3. Identification of novel classes of protein kinase inhibitors using combinatorial peptide chemistry based on functional genomics knowledge. Lukas TJ, et al. J Med Chem. 1999 Mar 11;42(5):910-9. |