CAS | 201422-04-0 |
Sequence | Myr-Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Ala-Val-Asp-Ala-Leu-OH |
Sequence Single | Myr-KKALRRQEAVDAL |
Molecular Formula | C78H142N22O20 |
Molecular Weight | 1708.12 |
Synonyms | Myr-AIP, AIP Myristoylated |
Technology | Synthetic |
Storage | -20°C, avoid light, cool and dry place |
Description | Autocamtide-2-related inhibitory peptide, myristoylated also called Myr-AIP, AIP Myristoylated, is the myristoylated Autocamtide-2-related inhibitory peptide. Autocamtide-2-related inhibitory peptide is a highly specific and potent inhibitor of CaMKII with an IC50 of 40 nM. |
References | 1. Neuroprotective effect of AIP on N-methyl-D-aspartate-induced cell death in retinal neurons. Laabich et al (2000). Brain Res.Mol.Brain Res. 85 32 PMID: 11146104 2. Inhibition of CaMKII activity in the nucleus accumbens shell blocks the reinstatement of morphine-seeking behavior in rats. Liu et al (2012). Neurosci.Lett. 518 167 PMID: 22579819 3. A novel highly specific and potent inhibitor of calmodulin-dependent protein kinase II. Ishida et al (1995). Biochem.Biophys.Res.Commun. 212 806 PMID: 7626114 4. A novel highly specific and potent inhibitor of calmodulin-dependent protein kinase II. Ishida A, et al. Biochem Biophys Res Commun. 1995 Jul 26;212(3):806-12. |