(Met5,Pro6,D-Phe7,D-Trp9,Phe10)-α-MSH (5-13) Melanocyte-Stimulating Hormone Catalog

CAS	158563-45-2
Sequence	H-Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH2
Sequence Single	MPfRwFKPV-NH2
Molecular Formula	C61H87N15O9S
Molecular Weight	1206.52
Synonyms	Nonapeptide-1
Technology	Synthetic
Storage	-20°C, avoid light, cool and dry place
Application	Cosmetic Peptides & Dermatology\|Pituitary & Hypothalamic Hormones
Description	(Met5,Pro6,D-Phe7,D-Trp9,Phe10)-α-MSH (5-13) also called Nonapeptide-1, Melanostatine-5, a peptide hormone, is a selective antagonist of MC1R (Ki: 40 nM). Nonapeptide-1 is a competitive α-MSH antagonist that potently inhibits intracellular cAMP and melanosome dispersion induced by α-MSH in melanocytes (IC50: 2.5 nM and 11 nM, respectively). Nonapeptide-1 inhibits melanin synthesis, and can be used in the research of skin pigmentation and regulation of steroid production in the adrenal gland, skin cancer.For MC1R, MC3R, MC4R and MC5R, the Ki value is 40 nM, 0.47 μM, 1.34 μM and 2.4 μM respectively.
References	1. A synthetic tumor necrosis factor-alpha agonist peptide enhances human polymorphonuclear leukocyte-mediated killing of Plasmodium falciparum in vitro and suppresses Plasmodium chabaudi infection in mice. L.M.Kumaratilake et al., J. Clin. Invest., 95, 2315 (1995) 2. Discovery and structure-function analysis of alpha-melanocyte-stimulating hormone antagonists. Jayawickreme CK, et al. J Biol Chem. 1994 Nov 25;269(47):29846-54. 3. Characterization of the binding of MSH-B, HB-228, GHRP-6 and 153N-6 to the human melanocortin receptor subtypes. Schiöth, H.B., et al. Neuropeptides 31(6), 565-571 (1997). 4. Effects of tea polyphenols on UVA-induced melanogenesis via inhibition of α-MSH-MC1R signalling pathway. Jiaoquan Chen, et al. Postepy Dermatol Alergol. 2022 Apr;39(2):327-335.

PeptideDB

(Met5,Pro6,D-Phe7,D-Trp9,Phe10)-α-MSH (5-13)

CAS No.: 158563-45-2